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. 2022 Oct 1;27(19):6492. doi: 10.3390/molecules27196492

Figure 5.

Figure 5

The influence of the tested compounds Norbo-4, Norbo-8, Norbo-10, Norbo-14, Norbo-18 and Norbo-20 (15 and 30 mg/kg) on motor coordination in mice evaluated in chimney (A) and rota-rod (B) tests. Investigated compounds were injected i.p. 60 min before the test. Data are expressed as mean ± SEM values of the 1 independent experiment. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control (Dunnett’s test). One-way ANOVA showed significant changes in the time in chimney after administration of the compound Norbo-4 (F(2,21) = 6.276; p < 0.01), Norbo-14 (F(2,21) = 5.615, p < 0.05 and Norbo-18 (F(2,21) = 5.381, p < 0.05) (A) and the time spent on the rota-rod for compound Norbo-4 (F(2,21) = 17.56; p < 0.0001), Norbo-14 (F(2,21) = 7.439, p < 0.01 and Norbo-18 (F(2,21) = 7.591, p < 0.01) (B). Dunnett’s post hoc test confirmed a significant increase of time in chimney after the administration of compound Norbo-4 administrated at the doses of 15 (p < 0.05) and 30 mg/kg (p < 0.01), Norbo-14 at the dose of 30 mg/kg (p < 0.01) and Norbo-18 at the dose of 30 mg/kg (p < 0.01) (A). These compounds decreased also time on rota-rod at the dose of 30 mg/kg (Norbo-4 (p < 0.001); Norbo-14 (p < 0.01) and Norbo-18 (p < 0.001)) (B).