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Reagents and conditions: (I) (R)-epichlorohydrin, THF, KF, 0°C~rt; (II) NH3H2O, EtOH, 80 °C; (III) ethyl 4-bromobenzoate, Pd(OAc)2, BINAP, K2CO3, Toluene, 120 °C; (IV) Pd(OAc)2, AcOH, 120 °C; (V) NaH, MeI, DMF; (VI) KOH, EtOH, H2O, 90 °C; (VII) HATU, DIEA, DCM.
