Scheme 2.
Reagents and conditions: (I) H2SO4, 4-hydrazinylbenzoic acid, H2O, 100 °C; (II) H2SO4, MeOH, 65 °C; (III) NaH, halogenated alkane, DMF, 0-r.t; (IV) KOH, EtOH, H2O, 90 °C; (V) HATU, DIEA, DCM.
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