Table 1.

Curcumin binding sites in p55 domain of VacA.

Site	Score	Predicted Binding Site Residues
Site 1	0.97	Asn618, Val620, Arg641, Val643, His669, Thr672, Phe674, Gly675, Ile676, Pro677, Lys680, Tyr729, Asn732, Asn733, Arg734, 737, Cys738, Val739, Arg741, Asp745, Ala748, Cys749, Vla752, Ala483, Asn529, Phe545, Asn546, Arg574, Phe565, Lys619
Site 2	0.951	Asn666, 668, 674, Thr675, Gly704, Asn705, Thr708, Gly709, Thr710, Asn711, Gly712, Ile713, Ser714, Val716, Asn717, Leu718, Glu720, Gln721, Lys723, Glu724, Arg725, Asp736, Asn737, Lys772, Trp774, Asn775, Ile776, 778, 779, 780, 803, Thr805, 806, 807, Pro808, Thr809, 810
Site 3	0.748	Tyr574, Ala595, Ser596, Pro599, Glu600, Pro602, Asp622, 623, Ser624, Asn643, Tyr644, Leu645, Arg647, Lys680, Ile681, Asn682
Site 4	0.642	Phe483, Asn484, Thr485, Ser504, Thr505, Asn506, Glu528, Thr529, His531
Site 5	0.541	Leu395, Ser396, Asn397, Gln398, Gly401, Arg402, Val421, Asn422, Thr428, Ala429, Leu430, Ser433, Ser434, Ala435