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Ghrelin’s synthesis and actions through brain–gut transport. Ghrelin is synthesized from preproghrelin and transported through blood circulation to the hypothalamus, where it stimulates growth hormone secretion. PKA, protein kinase A; Camp, cyclic adenosine monophosphate; MAPK, mitogen-activated protein kinase; PKC, protein kinase C; GH, growth hormone; GOAT, ghrelin-o-acyltransferase. Created with BioRender.com.
