Table 31.
Antidiabetic potential of the compounds (ad4–ad6) in alloxan-induced diabetic rats.
| Comp. | Blood Glucose Level (mg/dL) | Log P | Change in Blood Glucose Level (from 1st to 6th Hour) | |||
|---|---|---|---|---|---|---|
| 0 h | 1 h | 3 h | 6 h | |||
| ad4 | 312 ± 12.78 | 270 ± 10.67 | 135 ± 9.89 | 127 ± 7.76 | 3.22 | 185 |
| ad5 | 303 ± 4.89 | 255 ± 7.56 | 211 ± 2.98 | 133 ± 10.56 | 2.95 | 170 |
| ad6 | 302 ± 5.98 | 273 ± 7.65 | 211 ± 7.34 | 137 ± 6.34 | 2.95 | 165 |
| Pioglitazone | 276 ± 4.84 | 213 ± 3.44 | 114 ± 5.49 | 89 ± 3.26 | 3.58 | 187 |
(N = 6) All data represent the mean ± SEM analyzed by one-way analysis of variance (ANOVA) using Dunnett’s multiple comparison test applied for statistical analysis.