Table 50.
Antidiabetic potential of the compounds (ad47–ad49) using an alloxan-induced model in rats.
| Comp. | Mean ± SEM Blood Glucose Level (mg/dL) | |||||
|---|---|---|---|---|---|---|
| 0 h | 2 h | 4 h | 6 h | 12 h | 15th Day | |
| ad47 | 259.33 ± 25.65 | 234.61 ± 17.45 | 209.33 ± 5.84 | 183.00 ± 3.21 | 161.65 ± 2.72 | 158.64 ± 2.90 |
| ad48 | 256.69 ± 16.19 | 224.00 ± 7.63 | 198.33 ± 1.76 | 177.64 ± 2.02 | 159.00 ± 2.08 | 159.00 ± 1.15 |
| ad49 | 253.00 ± 8.71 | 230.64 ± 4.33 | 207.65 ± 2.33 | 175.61 ± 3.93 | 162.34 ± 2.90 | 159.00 ± 0.57 |
| Pioglitazone | 310.64 ± 8.09 | 165.00 ± 3.60 | 145.67 ± 4.09 | 137.00 ± 2.64 | 119.33 ± 2.96 | 104.33 ± 2.33 |
(N = 6) All data are given as mean ± SEM analyzed by one-way analysis of variance (ANOVA) followed by Dunnett’s test.