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. 2022 Oct 10;27(19):6763. doi: 10.3390/molecules27196763

Table 65.

Patent grant information of the thiazolidinedione analogues.

S. No. Patent No. Title Procedure/Activity Reference
1 WO/2019/016826 Novel 5-[4-(2-biphenyl-4-yl-2-oxo-ethoxy)-benzylidene]-thiazolidine-2,4-diones, their synthesis, and uses thereof. Antidiabetic activity [93]
2 WO/2002/026735 Sodium salts of 5-’4-’2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione. Synthetic procedure [94]
3 WO/2006/010345 Salt of oxalic acid with 5-[4-[2-(n-methyl-n-(2-pyridyl)-amino)ethoxy]benzyl]thiazolidin -2,4-dione and a method of its preparation and its use. Antidiabetic activity [95]
4 US 6,784,184 B2 5-(arylsulfonyl)-,5-(arylsulfinyl) and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for the inhibition of farnesyl-protein transferase. Anticancer activity [96]
5 WO/2003/053962 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyl)thiazolidine-2, 4-dione malic acid salt and its use against diabetes mellitus. Antidiabetic activity [97]
6 US 2020/0093812 A1 5-[[4-[2-[5-(1-Hydroxyethyl)pyridin-2-yl] ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione for treating nonalcoholic fatty liver disease. Treatment of non-alcoholic fatty liver disease [98]
7 EP0508740A1 Thiazolidinedione derivatives, their production, and their use. Hypoglycemic and hypolipidemic activity [99]
8 WO03053367A2 Hydrogenation of precursors to thiazolidinedione antihyperglycemics. Anti-hyperglycemic activity [100]
9 CN101531657A Dimethyldiguanide of the thiazolidinedione pharmaceutical, preparation method and use thereof. Anti-diabetic activity [101]
10 CN104230915A Thiazolidinedione-containing phenylpiperazine derivatives, as well as the preparation method and applications of thiazolidinedione-containing phenylpiperazine derivatives. Anti-cancer activity [102]
11 WO2010077101A2 Novel thiazolidinedione derivative and use thereof. Treatment of CVS, renal disease, and GIT disease [103]
12 JP2002322177A Thiazolidinedione derivative. Anticancer activity [104]
13 WO2007109037A2 Thiazolidinedione analogues. Antihypertensive activity [105]
14 WO2017021634A1 Association between 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl] methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione and a tyrosine kinase inhibitor of the EGFR. Anticancer activity [106]