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. 2022 Sep 21;14(19):3920. doi: 10.3390/nu14193920

Figure 2.

Figure 2

Wogonin induces Atf4 and Fgf21 expression. (A) Wogonin increased Fgf21 expression in AML12 cells. Cells were treated with 10 and 20 µM of baicalin, baicalein, and wogonin for 48 h. n = 4 per group. (B) Gene expression of FGF21-regulating transcription factors in AML12 cells. Cells were treated with 10 and 20 µM of wogonin for 48 h. n = 4 per group. (C) Wogonin increased the protein levels of ATF4 in AML12 cells. Cells were treated with 10 and 20 µM of wogonin for 48 h. The protein bands were quantified. n = 4 per group. (D) Wogonin increased the expression of genes regulated by ATF4 in AML12 cells. Cells were treated with 10 and 20 µM of wogonin for 48 h. n = 4 per group. Data are represented as mean ± SD. * p < 0.05; ** p < 0.01. Comparisons among multiple groups were assessed using one-way ANOVA, followed by Tukey’s post hoc test.