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Deficiency of ATF4 suppresses wogonin-induced Fgf21 expression. Fgf21 expression was suppressed by transfecting AML12 cells with siRNA against ATF4. After 24 h of transfection, cells were treated with 20 µM of wogonin for 48 h. n = 4 per group. Data are represented as mean ± SD. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. Comparisons among multiple groups were assessed using one-way ANOVA, followed by Tukey’s post hoc test.
