Figure 4.

As far back as the 1960s and 1970s there have been clinical trials examining the role of systemic therapy combined with radiotherapy. Notably, the Walker Series first examined combining CCNU and radiotherapy in the Brain Tumor Study Group protocols BTSG 66-01, 69-01, 72-01. More recently, the Stupp trial changed the standard of care to include Temozolomide concurrently with radiotherapy. As technological advancements have been made, there has also been an interest in the potential role of proton based radiotherapy, which is being explored in the BN001 trial. Finally, with the advent of the MRLinac, it is necessary to determine the role it may play in the treatment of GBMs.