Figure 3.

Antidepressant use and 28-day all-cause mortality in a matched analytic sample of patients hospitalized with COVID-19 (N = 1482). (A) Mortality rates in COVID-19 inpatients with and without an antidepressant at baseline in a matched analytic sample based on age, sex, hospital, period of hospitalization, number of medical conditions, any current diagnosis of psychiatric disorders, use of other psychotropic medications (benzodiazepines or Z-drugs, antipsychotic medications, mood stabilizers) or any medication prescribed according to compassionate use or as part of a clinical trial, and clinical and biological markers of COVID-19 severity; (B) associations between antidepressant use at baseline and 28-day mortality, stratified by age, sex, and period of hospitalization; (C) comparison of baseline use of antidepressants, fluoxetine, and fluoxetine or fluvoxamine with baseline use of dexamethasone and tocilizumab; (D) associations across antidepressant classes; abbreviations: ns, not significant.