TABLE 1.
Skin test and IFN-γ responses to mycobacterial antigens in healthy controls and in patients with disease due to M. tuberculosis or to MAC
| Subject | Skin test result
(mm)
|
IFN-γ response (ODI)
|
|||
|---|---|---|---|---|---|
| PPD | MAS | PPD | MAS | rESAT-6a | |
| Controls (n = 8) | |||||
| 1 | 0 | 0 | 1.1 | 1.5 | 1.0 |
| 2 | 0 | 0 | 3.0 | 8.9 | 1.1 |
| 3 | 0 | 0 | 14.3 | 1.1 | 1.4 |
| 4 | 0 | 0 | 5.0 | 1.2 | 1.1 |
| 5 | 0 | 0 | 2.3 | 1.0 | 1.1 |
| 6 | 0 | 0 | 1.4 | 1.0 | 1.1 |
| 7 | 0 | 0 | 2.9 | 1.0 | 1.0 |
| 8 | 0 | 0 | 1.0 | 1.0 | 1.1 |
| Mean | 3.9 | 2.1 | 1.1 | ||
| Patients with MAC pulmonary disease (n = 8) | |||||
| 1 | 4 | 21 | 1.7 | 2.8 | 1.0 |
| 2 | 0 | 13 | 2.7 | 7.9 | 1.0 |
| 3 | 0 | 17 | 8.6 | 13.9 | 1.0 |
| 4 | 0 | 14 | 1.2 | 1.4 | 1.0 |
| 5 | 0 | 0 | 1.1 | 1.4 | 1.0 |
| 6 | 0 | 0 | 1.1 | 1.2 | .9 |
| 7 | 5 | 18 | 1.5 | 1.0 | .9 |
| 8 | 1 | 10 | 1.2 | 2.2 | 1.0 |
| Mean | 2.4 | 4.0 | 1.0 | ||
| Patients with M. tuberculosis pulmonary disease (n = 27) | |||||
| 1 | 0 | 0 | 4.5 | 5.2 | 1.0 |
| 2 | 19 | 13 | 4.3 | 2.8 | 1.0 |
| 3 | 22 | 23 | 8.3 | 2.9 | 4.5 |
| 4 | 26 | 25 | 8.7 | 5.9 | 2.0 |
| 5 | 30 | 25 | 2.5 | 2.2 | .9 |
| 6 | 18 | 18 | 1.6 | 1.2 | 1.1 |
| 7 | 22 | 20 | 10.3 | 10.6 | 8.8 |
| 8 | 16 | 20 | 9.2 | 9.1 | 8.4 |
| 9 | 18 | 14 | 4.7 | 5.7 | 1.3 |
| 10 | 24 | 26 | 5.5 | 3.7 | 2.3 |
| 11 | 24 | 23 | 14.9 | 13.1 | 2.1 |
| 12 | 25 | 19 | 6.3 | 4.9 | 3.4 |
| 13 | 23 | 15 | 9.1 | 9.0 | 8.1 |
| 14 | 19 | 24 | 14.0 | 13.8 | 1.1 |
| 15 | 24 | 17 | 16.1 | 12.9 | 9.7 |
| 16 | 20 | 15 | 17.9 | 18.6 | 18.3 |
| 17 | 21 | 19 | 24.7 | 26.2 | 1.9 |
| 18 | 18 | 35 | 7.1 | 3.8 | 1.1 |
| 19 | 23 | 27 | 11.9 | 13.4 | 1.1 |
| 20 | 64 | 34 | 13.6 | 10.7 | 11.4 |
| 21 | 70 | 60 | 11.3 | 12.1 | 13.1 |
| 22 | 30 | 15 | 16.3 | 17.5 | 16.9 |
| 23 | 68 | 35 | 3.9 | 3.6 | 3.1 |
| 24 | 12 | 0 | 1.0 | 1.0 | 1.0 |
| 25 | 56 | 21 | 2.1 | 2.1 | 1.6 |
| 26 | 27 | 26 | 1.1 | 1.4 | 1.0 |
| 27 | 43 | 21 | 1.6 | 3.1 | 2.6 |
| Mean | 8.6 | 8.0 | 4.8 | ||
rESAT-6, recombinant ESAT-6.