Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Examples of the small-molecule control of engineered Acr proteins. (A) Destabilized AcrIIA4-DHFR fusion is stabilized by TMP to switch off genome editing. (B) Acr proteins fused to an engineered intein are spliced by binding to 4HT, and the activated Acr proteins inhibit genome editing. (C) AcrIIA4 fused to mAID is degraded by auxin that acts as a molecular glue in plant cells, and dSpCas9 is activated.
