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. 2022 Oct 17;17:362. doi: 10.1186/s13023-022-02517-0

Table 1.

Observational registries versus clinical trials

Characteristics Registries Clinical studies
Purpose Real-world observations Controlled experiments
Duration Indefinite Finite
Inclusion criteria General Specific
Data collection Voluntary Required
Visits Per medical practice Per protocol
Analytical methods Epidemiology Biostatistics
Disease characteristics Cross-sectional, longitudinal Per protocol
Treatment outcomes Long-term effectiveness Efficacy and safety
Applicability Broad patient populations Per protocol