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. 2022 Oct 16;13(10):874. doi: 10.1038/s41419-022-05320-8

Fig. 2. Functional heterogeneity of GC CAFs.

Fig. 2

CAFs play an essential role in the process of tumorigenesis and cancer progression such as GC cell proliferation, stemness, metabolic changes, and chemoresistance, as well as invasion, migration, EMT, angiogenesis, and immunosuppression in GC by releasing multiple ECM proteins and regulatory molecules.