Fig. 3. Hyper-activation of white matter pathways in schizophrenia.

Hyper-activated clusters are depicted on a mosaic of axial views on a segmented white matter template in stereotactic space. The binarized tractography mask is visible as an overlay on the template (in grayscale). Inspection of the mask emphasizes its circumscribed nature relative to all of the segmented white matter. Clusters are overlaid on the tractography mask. a Under the main effect group, schizophrenia patients were characterized by significant patterns of hyper-activation in longitudinal and transverse white matter tracts. These patterns were unpacked within each of the b within-hemispheric and c inter-hemispheric conditions. The degree of hyper-activation scales by the task condition, with greater hyper-activation, observed under the inter-hemispheric condition. The patterns of hyper-activation in mid-line callosal structures are further detailed in Fig. 4.