Table 3.
Results of the meta-analysis for brain activation difference between SZ and HC during reward outcome stage.
| Brain regions | MNI | SDM value | p value | Number of voxels | Breakdown |
|---|---|---|---|---|---|
| coordinates | |||||
| x, y, z | |||||
| P > HC | |||||
| Right striatum | 28,10,−14 | 1.829 | 0.000118673 | 590 |
Right lenticular nucleus, putamen, BA 48 Right striatum Right amygdala, BA 34, BA 48 Right olfactory cortex, BA 11, BA 48 Right inferior network, inferior fronto-occipital fasciculus Right parahippocampal gyrus, BA 34, BA 48 Right insula, BA 48 Right superior frontal gyrus, orbital part, BA 11 Right inferior frontal gyrus, orbital part, BA 11, BA 48 Right lenticular nucleus, putamen, BA 47 Right temporal pole, superior temporal gyrus, BA 34 Right hippocampus, BA 34 |
| Left striatum | −22,0,2 | 1.696 | 0.000289023 | 439 |
Left amygdala, BA 20, BA 28, BA 34 Left striatum Left lenticular nucleus, putamen, BA 48 Left insula, BA 48 Left pons Left inferior network, uncinate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus Left hippocampus, BA 34 Left superior temporal gyrus, BA 48 |
| Left cerebellum | −8,−36,−18 | 1.443 | 0.001243770 | 194 |
Left cerebellum, hemispheric lobule IV / V, BA 19, BA 30,, BA 37 Left cerebellum, hemispheric lobule VI, BA 19, BA 37 Left cerebellum, hemispheric lobule III, BA 30 Middle cerebellar peduncles Left cerebellum, hemispheric lobule VI, BA 18 |
| Right parahippocampal gyrus | 30,−4,−26 | 1.676 | 0.000314832 | 176 |
Right fusiform gyrus, BA 20, BA 36 Right inferior network, inferior longitudinal fasciculus, uncinate fasciculus Right parahippocampal gyrus, BA 20, BA 28, BA 35, BA 36 Right median network, cingulum Right amygdala, BA 28, BA 36 Right hippocampus, BA 36 |
| Right postcentral gyrus | 52,−18,56 | 1.443 | 0.00120765 | 31 |
Right postcentral gyrus, BA 4, BA 6 Right precentral gyrus, BA 4, BA 6 Right middle frontal gyrus, BA 6 |
| Right MCC | 8,34,30 | 1.438 | 0.001398563 | 20 | Right median cingulate / paracingulate gyri, BA 32 |
| P < HC | |||||
| mPFC | −10,52,6 | −1.129 | 0.000010312 | 817 |
Left anterior cingulate / paracingulate gyri, BA 10, BA 11, BA 32 Left superior frontal gyrus, medial, BA 10, BA 32 Left superior frontal gyrus, medial orbital, BA 10, BA 11 Right superior frontal gyrus, medial orbital, BA 10, BA 11 Left gyrus rectus, BA 11 Left median network, cingulum Right superior frontal gyrus, medial, BA 10 Right gyrus rectus, BA 11 Right anterior cingulate / paracingulate gyri, BA 10, BA 11 |
| Left DLPFC | −24,56,20 | −1.033 | 0.000051618 | 442 |
Left middle frontal gyrus, BA 9, BA 10, BA 46 Left superior frontal gyrus, dorsolateral, BA 9, BA 10, BA 46 |
| Right DLPFC | 22,20,62 | −1.036 | 0.000025809 | 143 | Right superior frontal gyrus, dorsolateral, BA 8 |
Results were threshold at p = 0.005, peak height threshold of 1, extent threshold of 10.
BA Brodmann area; P patients; HC healthy controls, MCC median cingulate cortex, mPFC medial prefrontal cortex, DLPFC dorsolateral prefrontal cortex, SDM seed-based d mapping, MNI Montreal Neurological Institute.