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. 2022 Oct 16;13:6110. doi: 10.1038/s41467-022-33787-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic describing the transfer of ex vivo-derived PCs into B-NDG (control; n = 7 animals from two independent experiments) and hIL-6-B-NDG knock-in (hIL-6; n = 8 animals from two independent experiments) mice. It was partially created with BioRender.com. b–d Firefly luciferase was quantified by IVIS imaging (normalized by Min-max normalization), hIgG and hIgM were quantified by ELISA and each point was plotted individually. The shadow represents the 95% confidence interval and the line represents the mean. P values were calculated in an unpaired two-sided t-test by comparing the area under curve (AUC) from individual mice. P values for normalized flux AUC and IgG AUC are 1.46E-05 and 1.37E-05, respectively. Source data are provided as a Source Data file. e, f Representative (e) and quantified (f) flow cytometry of BM cells from sacrificed mice using the indicated antibodies (control; n = 7 animals from two independent experiments) and hIL-6-B-NDG knock-in (hIL-6; n = 8 animals from two independent experiments). Data were presented as mean ± SD. P values were calculated using an unpaired one-sided t-test. Source data are provided as a Source Data file. g The relationship between hIgG antibody concentration and hIgG PCs counts in B-NDG mice and hIL-6-B-NDG mice. The correlation between them is presented by the Pearson correlation coefficient based on their quasi-linear relationship and assumption of normality of variables. The line indicates the mean at each time point, and the shadow shows the 95% confidence intervals. Source data are provided as a Source Data file.