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. 2022 Oct 3;13:1015585. doi: 10.3389/fimmu.2022.1015585
AAC activating antigen carriers human RBCs squeeze processed with antigen and poly I:C adjuvant
AAC-E7 mouse RBCs squeeze processed with E7 HPV SLP antigen and poly I:C adjuvant
AACHPV human RBCs squeeze processed on the research scale with E6 and E7 HPV SLP and poly I:C adjuvant
AAC-Ova mouse RBCs squeeze processed with ovalbumin antigen and poly I:C adjuvant
AC antigen carrier human RBCs squeeze processed with antigen (no adjuvant)
AC-E7 mouse RBCs squeeze processed with E7 HPV SLP antigen (no adjuvant)
AC-Ova mouse RBCs squeeze processed with ovalbumin antigen (no adjuvant)
AF Alexa Fluor
APC antigen presenting cell
AT adoptive transfer
AU arbitrary units
CD cluster of differentiation
cDC1 classical type 1 dendritic cell
CFSE carboxyfluorescein succinimidyl ester
C-media human RBCs squeeze processed with media (in the absence of antigen or adjuvant)
CMV cytomegalovirus
C-poly I:C human RBCs squeeze processed with poly I:C (no antigens)
CTLA-4 cytotoxic T-lymphocyte-associated protein 4
DC dendritic cell
EC empty carrier
FAM 5-carboxy-fluorescein
FOV field of view
FSC forward scatter
gMFI geometric mean fluorescence intensity
HPV human papilloma virus 16
ICS intracellular cytokine staining
IFN interferon
IL interleukin
MoDC monocyte derived dendritic cell
MOA mechanism of action
NOAEL no-observed-adverse-effect level
Ova ovalbumin
PBS phosphate-buffered saline
PBMC Peripheral blood mononuclear cells
PD-1 programmed cell death protein 1
poly I:C polyinosinic-polycytidylic
PS phosphatidylserine
PSI pound per square inch
RES reticuloendothelial system
RBC red blood cell
ROI region of interest
RO retro-orbital
RPM red pulp macrophages
SLP synthetic long peptide
SQZ-AAC-HPV human RBCs squeeze processed on the clinical scale with E6 and E7 HPV SLP and poly I:C adjuvan
SSC side scatter
TGF transforming growth factor
TLR toll-like receptor