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. 2022 Oct 3;13:1002163. doi: 10.3389/fimmu.2022.1002163

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Copyright © 2022 Kwack, Zhang, Kramer, Thiyagarajan, Lamb, Arao, Bard, Seldeen, Troen, Blackshear, Abrams and Kirkwood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M-MDSCs are expanded except in the bone marrow of cTTPKO mice. (A) Flow cytometry analysis of M-MDSC populations in bone marrow, spleen, and mesenteric lymph nodes from control and cTTPKO mice. (B) Flow cytometry analysis of PMN-MDSCs in bone marrow, spleen, and mesenteric lymph nodes from control and cTTPKO mice. (C) Flow cytometry analysis of macrophage populations in bone marrow, spleen, and mesenteric lymph nodes from control and cTTPKO mice. (D) Proliferated CD4⁺ T cell with anti-CD3/CD28 are shown in pink. CD4⁺ T cell proliferation assay using MDSCs isolated from control (grey) and cTTPKO (blue) mice. (E) Proliferated CD8⁺ T cell with anti-CD3/CD28 are shown in pink. CD8⁺ T cell proliferation using MDSCs isolated from control (grey) and cTTPKO (blue) mice. One-way analysis of variance with Tukey’s multiple comparisons test and unpaired t tests were used; data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.