Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 3;13:1002163. doi: 10.3389/fimmu.2022.1002163

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Kwack, Zhang, Kramer, Thiyagarajan, Lamb, Arao, Bard, Seldeen, Troen, Blackshear, Abrams and Kirkwood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Transcriptional profiling of bone marrow-derived cells reveals distinct differentiation landscapes in bone marrow of TTPKO/cTTPKO mice as well as in M-MDSCs. (A) Integrated Seurat analysis of samples from total mouse bone marrow displayed in UMAP. (B) UMAP of control, cTTPKO, and TTPKO mice bone marrow samples displayed individually. (C) The percentage of neutrophils, monocytes, and macrophages from control, cTTPKO, and TTPKO mice, plotted as a percentage of total cells sequenced in each sample. (D) Subpopulations of monocyte clusters are shown in red, and 10 distinct sub-clusters were reconstructed and displayed as UMAP. (E) Expression of M-MDSC specific panel (score) is shown in violin plot. (F) M-MDSC populations of control, cTTPK, and TTPKO mice are individually displayed in UMAP and compared graphically. (G) Dot plot showing top genes in which M-MDSC populations are differentially expressed in control, cTTPKO, and TTPKO mice.