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. 2022 Oct 3;10:953590. doi: 10.3389/fbioe.2022.953590

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Copyright © 2022 Yang, Zhang, Tan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Keratoconus (KC) is related to changes in mechanical cues. In KC, β-catenin in corneal epithelial cells acts as a mechano-transducer of substrate stiffness that induces abnormal differentiation and structural changes in the corneal epithelium by delocalizing from the membrane to the cytosol. Furthermore, mechanical stretch promotes the expression of several proteases and aggravates extracellular matrix (ECM) degradation via YAP and its cooperator, TEA domain transcription factor (TEAD), in stromal cells.