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. 2022 Oct 3;9:994160. doi: 10.3389/fmed.2022.994160

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Copyright © 2022 Hvidt, Baerends, Søgaard, Stærke, Raben, Reekie, Nielsen, Johansen, Wiese, Benfield, Iversen, Mustafa, Juhl, Petersen, Ostrowski, Lindvig, Rasmussen, Schleimann, Andersen, Juhl, Dietz, Andreasen, Lundgren, Østergaard, Tolstrup and the ENFORCE Study Group.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutralizing antibody responses to pseudoviral SARS-CoV-2-S after COVID-19 vaccination: (A) The 50% neutralization titers (NT50) induced by primary COVID-19 vaccination with BNT162b2 (n = 22), mRNA-1273 (n = 24), ChAdOx1/mRNA (n = 20) or Ad26.COV2.S (n = 19) quantified by the pseudovirus neutralization assay. Data from convalescent comparators (n = 25) are also displayed, but are not included in the statistical analysis. (B) NT50 values merged for all vaccine types. (C) The frequency of quantifiable (> 25) and non-quantifiable (≤ 25) NT50 values merged for all vaccine types. From left to right: SARS-CoV-2-S wt (Wuhan-Hu-1 including D614G) and the following SARS-CoV-2-S VOCs: B.1.1.7 (Alpha), B.1.617.2 (Delta), B.1.351 (Beta) and B.1.1.529; BA.1 (Omicron) (B.1.1.529; BA.1, n = 32: eight individuals per vaccine group). All boxplots present the lower quartile, median and upper quartile, and the error bars indicate 95% CI. P-values were indicated as follows: *p ≤ 0.05, ^**p < 0.01, and ^****p < 0.0001.