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. 2022 Oct 3;10:947337. doi: 10.3389/fcell.2022.947337

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Copyright © 2022 Lin, Chen, Peng, Xiang, Xiao, Chen, Cui, Huang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome wide of MERIP-seq and the distribution of m⁶A peaks in the keloid tissue and in the normal skin tissue. (A) Protein level of the METTL3 and WTAP methyltransferases in two types of tissues. n = 3 samples were randomly selected from each group in the WB experiments, *p < 0.05. (B) Signal heatmaps of unique and shared m⁶A peaks between the keloid and normal skin. The signal was presented with the value of log2 fold change of the distinct m⁶A peak sets. (C) Summary of m⁶A-modified genes identified in both groups. (D) Distribution of m⁶A peaks in the genic regions of the two groups.