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. 2022 Oct 3;10:947337. doi: 10.3389/fcell.2022.947337

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Copyright © 2022 Lin, Chen, Peng, Xiang, Xiao, Chen, Cui, Huang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Positive effects of hypermethylation on the expression of fibroblasts in keloid. Three-color immunofluorescence confocal images were obtained for WTAP (green), S100A4 (pink), and nuclei (blue) in normal skin and keloid. The images were merged at last. The two bars show that the proportion of the cells with WTAP staining and the cells with both positive staining of WTAP and S100A4 in keloid were significantly higher than those in normal skin. ****p < 0.0001.