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. 2022 Oct 3;13:941834. doi: 10.3389/fendo.2022.941834

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Copyright © 2022 Mahbub, Aslam, Elzubier, El-Boshy, Abdelghany, Ahmad, Idris, Almaimani, Alsaegh, El-Readi, Baghdadi and Refaat

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Co-detection of apoptotic bodies by TUNEL (green) with cleaved Casp-3 (red) by immunofluorescence in male mouse colonic tissues from all the study groups (40× objective; scale bar = 8 µm). Moreover, (B) the relative expression of Casp-3 protein alongside apoptosis index and (C) in male mouse colonic tissues concentrations of survivin and cytochrome C proteins from all groups are as graph bars (mean ± SD; ^aP< 0.05 compared with the NC group; ^bP< 0.05 compared with the PC group; ^cP< 0.05 compared with E2 monotherapy; ^dP< 0.05 compared with P4 monotherapy and ^eP< 0.05 compared with EP concurrent dual therapy protocol).