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. 2022 Oct 3;10:1001558. doi: 10.3389/fcell.2022.1001558

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Copyright © 2022 Yin, Liu, Tian, Fan, Ye, Meng, Wei, Xiong, Li, He and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aberrant DNA methylation at gene loci may be involved in immune response-related gene misregulation. (A) Pie chart (without annotation of TEs) demonstrates distribution of DMRs in human genome. (B) Scatter plot of the relationship between DNA methylation differences at gene promoter and their expression differences. (C) Functional enrichment of upregulated/downregulated genes with hypo/hyper-DMRs in gene promoter regions by Metascape. (D) Scatter plot of the relationship between DNA methylation differences at gene body and their expression differences. (E) Functional enrichment of upregulated/downregulated genes with hypo/hyper-DMRs in gene body regions by Metascape.