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. 2022 Oct 3;12:1024600. doi: 10.3389/fonc.2022.1024600

Figure 1.

Figure 1

Super-enhancer and enhancer RNA (eRNA). (A) Identification of super-enhancers (16). The higher density of transcriptional regulators through cooperative binding to genomic regions contribute to both activated histone acetylation and higher transcriptional output at super-enhancers. K27: lysine 27. (B) Impacts of enhancer RNAs (eRNAs) at super-enhancers. Highly transcribed eRNAs facilitate formation of loop between promoters and enhancers.