Table 2.

Summary of molecules for targeting phase-separation for treating treatment-resistant malignancy.

Protein complex	Molecules/Screning	Molecular function	Tumor model	Ref
HOXB8/FOSL1	GSK-J4 Screening by 303 chemicals	H3K27 demethylase inhibitor	Osteosarcoma	118
SRC3/NSD2	SI-2 High throughput cell-based luciferase assay screening	small molecules interacting with SRC-3	Multiple myeloma	119, 120
OCT4/AR/FOXA1 OCT4/NRF1	Ribavirin In silico screening by using Connectivity Map	nuclear analogue	Prostate cancer	81, 113
YAP/TAZ/SRC1	Elvitegravir YAP reporter cell-based screening	integrase inhibitor	Lung cancer	121