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. 2022 Oct 3;10:1016951. doi: 10.3389/fcell.2022.1016951

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Copyright © 2022 Mladenova, Mladenov, Chaudhary, Stuschke and Iliakis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model describing the altered DSB repair pathway balance in simple versus complex DSBs (A) Simple DSBs engage repair by both c-NHEJ and DNA end-resection dependent pathways, which results in low level of SCAs formation. (B) DSBs clusters suppress the repair by c-NHEJ thus allowing the involvement of error-prone DNA end-resection dependent repair pathways. This manifests in the increased level of SCAs when alt-EJ and SSA are involved in repair. Elevated number of RAD51 foci indicates the involvement of HR in the repair of DSB-clusters; However, it remains unclear to what extent HR is productive.