Table 3.
Association analysis between the PAX-1 polymorphisms and scoliosis severity, considering the lumbar spine modifier of Lenke's classification (n=59)
| PAX-1 SNP | A (n=40), | B and C (n=19) | P * | ORa‡ (95% CI) |
|---|---|---|---|---|
| rs6137473 | n (%) | n (%) | ||
| AA | 14 (35.0) | 1 (5.3) | 1† | |
| AG | 22 (55.0) | 14 (73.7) | 0.041 | 8.50 (0.99-73.0) |
| GG | 4 (10.0) | 4 (21.0) | 4.83 (1.15-20.4) | |
| A | 50 (62.5) | 16 (42.1) | 1† | |
| G | 30 (37.5) | 22 (57.9) | 0.047 | 2.52 (1.10-5.77) |
| rs169311 | ||||
| CC | 11 (27.5) | 1 (5.3) | 1† | |
| CA | 21 (52.5) | 13 (68.4) | 0.141 | 7.00 (0.77-64.0) |
| AA | 8 (20.0) | 5 (26.3) | 2.48 (0.69-8.95) | |
| C | 43 (53.8) | 15 (39.5) | 0.171 | 1† |
| A | 37 (46.2) | 23 (60.5) | 1.95 (0.86-4.43) |
*Pearson's Chi-square test or Fisher's exact test, when necessary; †Reference group; ‡ORa - Odds ratio adjusted by age, gender, and BMI. SNP - Single-nucleotide polymorphism; OR - Odds ratio; CI - 95% confidence interval; BMI - Body mass index