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Mechanisms of regulation of HDACs and signaling pathways associated with resistance to therapies in lung cancer. Epigenetic therapies with HDAC inhibitors regulate different signaling pathways, proteasome activity, and transcriptional repression of genes involved in the cancer hallmarks of lung cancer. Created with Biorender.com.
Phosphorylation 
Acetylation 
Up-regulation 
Activation 
Inhibition 
Mechanism promoted by treatments
