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. 2022 Oct 3;13:960263. doi: 10.3389/fgene.2022.960263

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Copyright © 2022 Contreras-Sanzón, Prado-Garcia, Romero-Garcia, Nuñez-Corona, Ortiz-Quintero, Luna-Rivero, Martínez-Cruz and Carlos-Reyes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Strategies of CSCs subpopulations that promote the phenotype resistant tumor cells to therapies mediated by HDACs in lung cancer. Created with biorender.com HDAC inhibitors (SAHA = Vorinostat, FT234, FT895); Ac, acetylation; TRIB1 = tribbles pseudokinase 1; C/EBP-β, CCAAT enhancer binding protein beta; YAP1, yes associated protein 1; SOX2, SRY-Box Transcription Factor 2; OCT4, Octamer-binding transcription factor 4; Bim-1, BMI1 Proto-Oncogene, Polycomb Ring Finger; PRC2, polycomb repressive complex 2; Suz-12 = SUZ12 Polycomb Repressive Complex 2 Subunit; EED, embryonic ectoderm development; RbAP 46/48, retinoblastomabinding protein p48; EZH2, Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit; OXPHOS, oxidative phosphorylation; ROS, reactive oxygen species.

Phosphorylation Acetylation Up-regulation Methylation Inhibition Mechanism promoted by treatments Activation

Inline graphic — Strategies of CSCs subpopulations that promote the phenotype resistant tumor cells to therapies mediated by HDACs in lung cancer. Created with biorender.com HDAC inhibitors (SAHA = Vorinostat, FT234, FT895); Ac, acetylation; TRIB1 = tribbles pseudokinase 1; C/EBP-β, CCAAT enhancer binding protein beta; YAP1, yes associated protein 1; SOX2, SRY-Box Transcription Factor 2; OCT4, Octamer-binding transcription factor 4; Bim-1, BMI1 Proto-Oncogene, Polycomb Ring Finger; PRC2, polycomb repressive complex 2; Suz-12 = SUZ12 Polycomb Repressive Complex 2 Subunit; EED, embryonic ectoderm development; RbAP 46/48, retinoblastomabinding protein p48; EZH2, Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit; OXPHOS, oxidative phosphorylation; ROS, reactive oxygen species.

Phosphorylation Acetylation Up-regulation Methylation Inhibition Mechanism promoted by treatments Activation