TABLE 2.

Structure of HDACs inhibitors against deacetylase isozymes in lung cancer and clinical assays.

Structure HDAC inhibitors	In vitro tests NSCLC cell lines	HDAC class	HDAC isozyme	HDAC Inhibition IC50 (nM)	Clinical assays	Reference
Panobinostat (LBH-589)	A549 Calu-1 H226 H460 H838 SKMES-1	Class I Class IIa Class IIb	HDAC-1 HDAC-2 HDAC-3 HDAC-8 HDAC-4 HDAC-7 HDAC-9 HDAC-6	4–31	Phase I Completed (NCT02890069)	Wang et al. (2018b)
Vorinostat (SAHA)	PC-14 A549 A549-Oct4 H460-luc	Class I Class IIa Class IIb	HDAC-1 HDAC-2 HDAC-3 HDAC-8 HDAC-4 HDAC-7 HDAC-9 HDAC-6	81.7 ± 1.4 281.0 ± 2.2 32.8 ± 1.6 >10 20.0 ± 0.2 ------ 1975.0 ± 35.0 ------	Phase I Completed (NCT01059552)	Shieh et al. (2017)
CG347B	A549 NCI-H460 NCI-H1299	Class IIb	HDAC-6	5000	Not yet evaluated	Wang et al. (2020b)
Pracinostat	LU505, DMS53	Class I Class IIa Class IIb Class IV	HDAC-1 HDAC-2 HDAC-3 HDAC-8 HDAC-4 HDAC-7 HDAC-9 HDAC-6 HDAC-11	125	Not yet evaluated	Jia et al. (2018)
Trichostatin A (TSA)	H1975 HCC827 A549	Class I Class IIb	HDAC-1 HDAC-2 HDAC-3 HDAC-6	81.3 232 400	Not yet evaluated	Tang et al. (2018), Meng et al. (2021)
CAY10603	A549 HCC827 H1975 C57BL/6 male mice	Class IIb	HDAC-6	10, 5 mg/kg	Not yet evaluated	Liu et al., 2019, Wang et al. (2016c)
SNOH-3	A549 NCI-H1299	Class I	HDAC-1	822	Not yet evaluated	Wang et al. (2016a)
MPT0E028	A549 H1299 H1975 PC9/IR CL97	Class I Class IIb	HDAC-1 HDAC-2 HDAC-8 HDAC-6	1550 ± 140 1100 ± 20 1300 ± 130 1660 ± 410 1350 ± 110	Not yet evaluated	Chen et al. (2013)
S11	A549 CDDP resistants H460 CDDP resistants H1299 CDDP resistants	Class I	HDAC-1 HDAC-2	1380 2320 139O	Not yet evaluated	Sun et al. (2019)
Mocetinostat	H23 H1299 H1437 H1703 H1792 H1838 H2122 CT26	Class I	HDAC-1 HDAC-2 HDAC-3 HDAC-8	1000	Phase II completed (NCT02954991)	Briere et al. (2018)
Valproic acid (VPA)	1. A549	Class I Class IIa	HDAC-1 HDAC-2 HDAC-3 HDAC-8 HDAC-4 HDAC-5 HDAC-7 HDAC-9	10.5 6.8 and 4.5	Phase I-II completed (NCT00084981, NCT00759824)	Kalantar et al., 2021
CUDC-907	H196 SHP77 DMD273 H446 H526 H69 H82 DMS79 H2066	Class I Class IIa Class IIb	HDAC-1 HDAC-2 HDAC-3 HDAC-8 HDAC-4 HDAC-5 HDAC-7 HDAC-9 HDAC-6 HDAC-10	0.49 3.91 3.55 1.69 1.00 2.22 2.22 8.83 0.70	Not yet evaluated	Ma et al. (2020)
Selisistat (EX527)	A549 H1299 H157 DMS53 and Calu-1 cell lines	Class III	SIRT	10,000 5000	Not yet evaluated	Chen et al. (2017a), Guo et al. (2021)
YF454A	A549 H1299 H1975 and PC9			150 to 3500	Not yet evaluated	Yu et al. (2017)

Refs (Chen et al., 2013; Wang L. et al., 2016; Wang et al., 2016c; Chen G. et al., 2017; Shieh et al., 2017; Yu et al., 2017; Wang L. et al., 2018; Jia et al., 2018; Tang et al., 2018; Luo et al., 2019; Sun et al., 2019; Ma et al., 2020; Zhang et al., 2020; Guo et al., 2021; Meng et al., 2021).