Table 3.
Summary of blood chemistry and biomarkers of inflammation.
| No AKI | AKI | P-value | |
|---|---|---|---|
| Sample size | 23 | 21 (15a) | |
| Blood urea nitrogen (mg/dL) | 18.0 [12.5, 28.0] | 66.0 [40.0, 100.0] | < 0.01 |
| Creatinine (mg/dL) | 0.7 [0.6, 0.8] | 2.5 [1.7, 3.3] | < 0.01 |
| White blood cell count (1000/µL) | 9.7 [5.7, 12.8] | 7.6 [6.1, 15.1] | 0.99 |
| Hemoglobin (g/dL) | 12.9 [12.1, 14.2] | 11.1 [9.4, 13.4] | < 0.01 |
| Platelets (1000/µL) | 207.0 [161.0, 270.0] | 163.0 [142.0, 202.0] | 0.21 |
| CO2 (mmol/L) | 28.0 [24.0, 30.0] | 23.0 [21.0, 27.0] | < 0.05 |
| Angiopoietin-2 (pg/mL) | 5490.8 [2173.8, 15,011.9] | 28,035.4 [3193.4, 41,064.9] | < 0.05 |
| Interleukin-8 (pg/mL) | 11.2 [7.3, 20.5] | 26.2 [18.3, 32.2] | < 0.05 |
| Interleukin-6 (pg/mL) | 21.7 [6.9, 37.8] | 82.6 [13.2, 114.8] | 0.16 |
| Procalcitonin (pg/mL) | 102.3 [67.9, 161.5] | 1039.5 [289.5, 2547.2] | < 0.01 |
| ST2 (pg/mL) | 117,938.8 [61255.1, 164,618.7] | 258,805.9 [188349.4, 433,301.3] | < 0.01 |
| Fractalkine (pg/mL) | 187.2 [185.1, 976.9] | 3264.7 [2024.9, 5311.8] | < 0.01 |
| Interleukin-10 (pg/mL) | 0.7 [0.6, 4.4] | 0.6 [0.6, 9.9] | 0.58 |
| Pentraxin-3 (pg/mL) | 6338.2 [2024.9, 11,203.5] | 19,529.0 [11424.0, 25,708.1] | < 0.01 |
| RAGE (pg/mL) | 12,837.2 [2567.6, 33,369.6] | 66,377.2 [7225.7, 124,459.9] | < 0.05 |
| TNFR-1 (pg/mL) | 2409.6 [1792.9, 3598.6] | 9297.0 [6966.2, 17,229.2] | < 0.01 |
aSample size for plasma biomarkers using Luminex analysis was 15. Values are median and interquartile range.