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An overview of the Kynurenine pathway (KP). The metabolites highlighted in red (3,HK; 3,HANA; and QUIN) are neurotoxic and KYNA which is highlighted in green is neuroprotective. L,TRP L,Tryptophan; L,KYN L,kynurenine; KYNA Kynurenic acid; 3,HK 3,Hydroxykynurenine; 3,HANA 3,Hydroxyanthranilic acid; QUIN Quinolinic acid; AA Anthranilic acid; IDO indoleamine 2;3,dioxygenase; TDO tryptophan 2;3,dioxygenase; KATs kynurenine aminotransferases; KMO.
