Table 4.
Statistical analysis of reviewed studies for AD.
| Metabolite | Materials | Number of studies | SMD | 95%CI | I2(%) | P-value for heterogenicity |
|---|---|---|---|---|---|---|
| TRP | CSF | 4 | -0.34 | (-0.97, 0.29) | 71.0 | 0.016 |
| Blood (serum/plasma) | 8 | -0.68 | (-0.97, 0.40) | 41.8 | 0.100 | |
| KYN | CSF | 3 | -0.62 | (-1.70, 0.45) | 84.0 | 0.002 |
| Blood (serum/plasma) | 6 | 0.62 | (-0.18, 1.43) | 92.0 | 0.000 | |
| KYNA | Blood (serum/plasma) | 5 | -1.03 | (-2.19, 0.13) | 94.1 | 0.000 |
| KYN/TRP | Blood (serum/plasma) | 5 | 0.46 | (-0.01, 0.92) | 72.9 | 0.005 |
| AA | Blood (serum/plasma) | 3 | -0.34 | (-0.72, 0.05) | 35.6 | 0.211 |
| 5HIAA | CSF | 4 | 0.36 | (-0.13, 0.84) | 53.9 | 0.089 |
| 3-HK | Temporal cortex/Hippocampi | 3 | 0.10 | (-0.39, 0.60) | 19.4 | 0.289 |
| CSF | 3 | -1.28 | (-2.35, -0.20) | 81.7 | 0.004 | |
| Blood (serum/plasma) | 3 | -0.05 | (-0.58, 0.49) | 71.1 | 0.031 |