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. 2022 Jul 28;28(13):2027–2037. doi: 10.1177/13524585221110585

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© The Author(s), 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Representative lesion masks. New T₂-w lesion masks (green) and spatially matched contralateral NAWM masks (blue) are overlaid on the pre-lesion (6 months prior to lesion appearance (T-6)) T₁-w anatomical (top) and T₂-w FLAIR (bottom) images. The anterior lesion (open arrow) is a discrete de novo lesion arising entirely from NAWM with no voxels spatially connected to existing lesions. The second lesion (open arrowhead) is an expanding/enlarging lesion, and the spatially matched contralateral NAWM ROI was manually adjusted to avoid an existing T₂ lesion while maintaining total ROI volume.