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Parametric maps showing lesion evolution. Parametric maps demonstrating lesion evolution in the de novo (open arrow) and expanding/enlarging (open arrowhead) lesions from Figure 1. AVF change is not visually appreciable in this slice at T0 in the de novo lesion, where axonal loss follows acute inflammation and demyelination. AVF, MVF, and T1 worsen progressively over time in both lesions, ultimately resulting in black-hole fate at T+12.
