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. 2022 Oct 3;13:985478. doi: 10.3389/fimmu.2022.985478

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Copyright © 2022 Desikan, Linderman, Davis, Zarnitsyna, Ahmed and Antia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Data and simulation of vaccination with the WU-vaccine followed by boosting with WU- vs OM-vaccines. (A) In Gagne et al. (28), individuals were vaccinated at times indicated by the yellow triangles), initially with the WU-vaccine on days 0 and 28. The authors found that a second boost (vaccination #3) at day 287 (week 41) with either the WU- or OM-vaccine resulted in comparable titers to the OM virus two weeks later. (Color coding same as in the legend for panel C). (B) Simulations with the same dosing regimen as Gagne et al. (28) reproduce the experimental trends seen in panel (A). (C) Simulated dynamics of antibody titers to WU- vs OM-antigens (corresponding to panel B).