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. 2022 Oct 3;13:909995. doi: 10.3389/fimmu.2022.909995

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Copyright © 2022 Longueira, Ojeda, Battistelli, Sanchez, Oviedo Rouco, Albano, Guevara, Valls, Pando and Gamarnik

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal antibodies measurements in fully vaccinated breastfeeding without previous infection. IgG and IgA anti-spike antibody levels measured as geometric means by OD at 450 nm in naïve mothers receiving Sputnik V C1 and C2 vaccine (Gamaleya, N= 4), ChAdOx1-S vaccine (AstraZeneca, N= 12) and BBIBP10 CorV vaccine (Sinopharm, N=12). Samples were obtained as a function of time at 44 (T1) and 120 (T2) days after second doses of Sputnik V, ChAdOx1‐S and BIBP-CorV vaccines. Cut-off for serum and breast milk samples resulted from the mean of OD450 values from negative controls plus 3 times the standard deviation and is shown as dotted line. Wilcoxon matched-pair test was used. Statistical significance is shown with the following notations: ****, P < 0.0001; ***, P < 0.001; *, P < 0.05; ns, not significant.