FIGURE 5.

Gene expression dynamics along the pseudotime of NK cell exhaustion. (A) pseudotime trajectory analysis of ZNF683⁺NK cells, transitional NK cells and CD56^bright NK cells with high variable genes. Each dot represents one single cell, colour‐coded according to its cluster label. The integrated diffusion maps of clusters of NK cells reveal a developmental trajectory with conserved ‘pseudo‐temporal’ dynamics. (B) Heatmap depicting expression of state‐specific markers obtained by monocle. (C) Gene expression variation in ZNF683⁺NK cells relative to immature NK cells were shown. (D) Heatmap show GO analysis results of state‐specific signalling pathways along the pseudo‐time