TABLE 1.
Downstream targets of IκBζ with the respective stimulus
| Target genes/proteins | Stimuli | Cells | Refs |
|---|---|---|---|
| IL‐6 | LPS; pneumococcal strain D39 | Swiss 3T3 cells; human monocytes; peritoneal macrophages | 6 , 45 , 46 |
| LCN2/ NGAL |
IL‐1β; TNFα and IL‐17 costimulation |
Epithelial cells; lung epithelial A549 cell line | 40 , 41 , 42 |
| IFNG |
IL‐18 and IL‐1β acting in synergy with TNFα IL‐12/IL‐18 |
KG1 cell line Human NK cells |
43 , 44 |
| DEFB4/ hBD‐2 | IL‐17A | Normal human bronchial epithelial cells | 39 |
| IL‐36γ | IL‐17A | Psoriatic keratinocytes | 47 |
| CCL2 (MCP‐1) | LPS or bacterial peptidoglycan |
In vivo zymosan peritonitis model |
48 |
| IL‐8 | γ‐irradiation | Glioma cells | 49 |
| CXCL1 | γ‐irradiation | Glioma cells | 49 |
| IL‐19 | IL‐17A and TNFα | Human keratinocytes | 53 |
| IL‐20 | IL‐17A and TNFα | Human keratinocytes | 53 |
| IL‐33 dependent cytokines and chemokines such as IL‐6, IL‐13, CCL2, CCL3, and TNFα | IL‐33 | Bone marrow‐derived mast cells | 54 |
CCL, chemokine (C‐C motif) ligand; Cxcl, chemokine (C‐X‐C motif) ligand; DEFB4, defensin beta 4; hBD‐2, human beta‐defensin 2; IFNG, interferon gamma; IL, interleukin; LCN2, lipocalin 2; LPS, lipopolysaccharide; MCP, monocyte chemoattractant protein; NGAL, neutrophil gelatinase‐associated lipocalin; TNFα, tumour necrosis factor‐alpha.