Table 4.

Influence of statistical model on TXA efficacy of inflammatory biomarkers IL-8, TNF-α, and NE.

Statistical model	Post-op 6 h: TNF-α, NE, pg/ml. WMD (95% CI)		Post-op 24 h: IL-8, TNF-α, NE, pg/ml. WMD (95% CI)
	TNF-α	NE	IL-8	TNF-α	NE
Random effects	−7.21 (−12.41, −2.01	−66.93 (−111.94, −21.92)	−36.83 (−68.84, −4.83)	−10.02 (−14.93, −5.12)	−141.27 (−290.85, 8.31)
Fixed effects	−5.49 (−7.57, −3.41)	−44.03 (−54.92, −33.13)	−16.85 (−23.03, −10.68)	−0.77 (−1.42, −0.13)	−35.19 (−42.11, −28.27)

Post-op, postoperative; WMD, weighted mean difference. ^a95% CI, 95% confidence interval; IL-8, interleukin-8; TNF-α, tumor necrosis factor alpha; NE, neutrophil elastase.