Table 2.
Laboratory Characteristics, by Disease Severity
| Characteristic | No. | Grade 0 (n = 42) |
No. | Grade 1 (n = 19) |
No. | Grade 2 (n = 8) |
P Valuea |
|---|---|---|---|---|---|---|---|
| Ferritin, ng/mL | 41 | 1879.8 (573.6–4696.4) | 19 | 2360.6 (831.0–10 528.3) | 8 | 4809.1 (2424.2–9832.6) | .239 |
| Fibrinogen, mg/dL | 41 | 295.5 (198.1–349.0) | 19 | 207.8 (153.7–266.7) | 8 | 301.6 (250.8–356.6) | .152 |
| Triglyceride, mg/dL | 41 | 112.7 (77.9–142.5) | 19 | 99.4 (84.0–127.0) | 8 | 170.2 (126.9–208.3) | .037b |
| Soluble CD25, ng/mL | 41 | 1.0 (0.7–1.3) | 19 | 1.0 (0.7–1.3) | 8 | 1.3 (0.7–2.2) | .497 |
| Soluble CD163, ng/mL | 41 | 374.7 (292.4–478.1) | 19 | 416.5 (278.7–507.3) | 8 | 485.2 (354.5–602.2) | .405 |
| IL-18, ng/mL | 41 | 309.0 (201.0–375.0) | 19 | 291.0 (241.5–366.0) | 8 | 346.5 (221.2–411.8) | .689 |
| IL-1Ra, ng/mL | 39 | 3.2 (2.3–7.1) | 17 | 6.9 (3.7–11.8) | 8 | 6.4 (2.2–9.1) | .198 |
| Peak ferritin >2000 ng/mL, No. (%) | 42 | 19 (45.2) | 18 | 14 (77.8) | 6 | 5 (83.3) | .027c |
| H-score | 42 | 105.5 (77.2–135.5) | 19 | 138.0 (107.5–167.0) | 8 | 148.5 (114.5–177.2) | .013c |
| Features of MAS, No. (%) | |||||||
| Fever ≥38.5°C | 42 | 15 (35.7) | 18 | 4 (22.2) | 6 | 1 (16.7) | .498 |
| 2-line cytopenia | 42 | 18 (42.9) | 18 | 10 (55.6) | 6 | 3 (50.0) | .695 |
| Hepatomegaly and/or AST >100 U/L | 42 | 6 (14.3) | 18 | 5 (27.8) | 6 | 2 (33.3) | .297 |
| Ferritin >5000 ng/mL | 42 | 13 (31.0) | 18 | 13 (72.2) | 6 | 3 (50.0) | .009c |
| Triglyceride >250 mg/dL or fibrinogen <150 mg/dL |
42 | 8 (19.0) | 18 | 4 (22.2) | 6 | 2 (33.3) | .652 |
Data are presented as median (interquartile range) unless otherwise indicated.
Abbreviations: AST, aspartate aminotransferase; IL, interleukin; MAS, macrophage activation syndrome.
P values based on Kruskal–Wallis test.
Significant difference was shown in pairwise comparisons between grade 2 and grade 0 and between grade 2 and grade 1 (Dunn test).
Significant difference was shown in pairwise comparison between grade 1 and grade 0 (Dunn test).