Table 3.
Kinetics of Biomarkers Over Illness Course
| Biomarker | No. | Days 1–3 (n = 19) |
No. | Days 4–5 (n = 50) |
No. | Days 6–7 (n = 42) |
No. | Days 8–10 (n = 13) |
No. | Day >10 (n = 14) |
|---|---|---|---|---|---|---|---|---|---|---|
| Ferritin, ng/mL | 18 | 587.3 (289.9–850.5) | 50 | 2549.3 (1069.5–7765.4) | 42 | 5428.9 (1715.8–14 213.2) | 13 | 3909.5 (2470.2–10 141.8) | 14 | 232.0 (186.4–444.0) |
| Fibrinogen, mg/dL | 18 | 288.2 (159.4–347.6) | 50 | 247.6 (171.8–333.5) | 42 | 285.8 (234.7–332.6) | 13 | 231.8 (173.3–336.0) | 14 | 321.5 (282.2–401.0) |
| Triglyceride, mg/dL | 18 | 85.5 (60.7–101.7) | 50 | 107.7 (92.0–140.8) | 42 | 133.4 (108.8–171.3) | 12 | 149.9 (90.7–182.8) | 14 | 204.8 (161.5–283.2) |
| Soluble CD25, ng/mL | 18 | 0.8 (0.6–1.1) | 50 | 1.1 (0.7–1.5) | 42 | 1.2 (1.0–1.7) | 13 | 1.2 (1.1–1.5) | 14 | 0.5 (0.4–0.7) |
| Soluble CD163, ng/mL | 18 | 367.1 (306.8–492.5) | 50 | 408.5 (296.1–513.1) | 42 | 411.4 (272.6–641.7) | 13 | 460.9 (359.4–692.3) | 14 | 434.5 (333.2–514.9) |
| IL-18, ng/mL | 18 | 244.5 (163.5–312.0) | 50 | 301.5 (231.7–366.0) | 42 | 309.0 (207.0–384.8) | 13 | 252.0 (213.0–300.0) | 14 | 199.5 (167.2–385.5) |
| IL-1Ra, ng/mL | 16 | 10.0 (5.9–12.0) | 47 | 4.2 (2.3–10.4) | 42 | 2.5 (1.5–3.5) | 12 | 1.8 (1.6–2.8) | 14 | 0.7 (0.5–1.0) |
Data are presented as median (interquartile range) unless otherwise indicated.
Abbreviation: IL, interleukin.