Figure 2. SLC15A4 ^feeble mice show faster recovery from acute dextran sodium sulfate‐induced colitis in mice.

WT and SLC15A4 ^feeble mice were given 2.5% DSS in drinking water for 5 days followed by normal drinking water for 10 more days or water only (naïve).

• A
  Mice in three independent experiments were weighed daily. Percent of body weight loss overtime is represented relative to day 1.
• B
  Stool consistency and presence of blood were assessed. Blood stool index on days 8 (left panel) and 16 (right panel) was determined using the following score: 0, normal feces, negative hemoccult; 1, soft but formed feces, positive hemoccult; 2, very soft feces, visible traces of stool blood; 3, diarrhea, rectal bleeding. Data from three independent experiments are shown.
• C
  Left panel. Colon length was measured on day 16. Data from three independent experiments are shown. Right panel. Representative image of three independent experiments.
• D
  Colon swiss roll samples were formalin‐fixed, paraffin embedded, stained, and scored blinded by expert pathologist. Left panel. Inflammation score on day 16. Data from three independent experiments are shown. Right panels. Representative haematoxylin and eosin stained, formalin‐fixed paraffin embedded samples. Note disrupted crypt architecture (arrows) and inflammatory infiltrate (arrowheads) in DSS‐treated WT samples. Scale bar, 300 μm.

Data information: Data represent mean ± SD in panel A. Mean is indicated in panels B, C, and D. **P < 0.01; ***P < 0.001; Mann–Whitney non‐parametric statistical test.

Source data are available online for this figure.