Table 5.

Odds ratios for the association between SARS-CoV-2 infection and ectopic pregnancy from multinomial logistic regression models

	Number of pregnancies	Number (%) of ongoing pregnancies	Number (%) of ectopic pregnancies	Odds ratio (95% CI)a	p-value	Adjusted Odds ratio (95% CI)b	p-value
Primary analysis (historical controls)
Uninfected	2745	1960 (71.4%)	33 (1.2%)	1		1
Infected	915	579 (63.3%)	8 (0.9%)	0.80 (0.37–1.75)	0.58	0.76 (0.34–1.69)	0.50
Supplementary analysis (contemporary controls)
Uninfected	2745	1901 (69.3%)	32 (1.2%)	1		1
Infected	915	579 (63.3%)	8 (0.9%)	0.82 (0.37–1.78)	0.61	0.78 (0.34–1.79)	0.56

All analyses exclude women who received COVID-19 vaccination between 6 weeks preconception and the earliest of either: end of pregnancy or the end of the exposure period at 2 + 6 weeks gestation.

CI confidence interval.

^aAdjusting for matching factors: maternal age and gestational age at the date of infection of index infected pregnancy (and season of conception for primary analysis).

^bAdditionally adjusting for deprivation, urban/rural status, and clinical vulnerability (and ethnicity and season of conception in supplementary analysis).