Figure 1.

GB1211 inhibits macrophage- and myofibroblast-driven fibrosis in cirrothic liver disease. Monocytes differentitiate into macrophages upon activation via, for example, inflammation, infection, or injury. This results in the release of TGFβ, PDGF, and galectin-3 which results in differentiation of epithelial cells into myofibroblasts which in turn release αSMA and deposit ECM. Galectin-3 is the key mediator in driving the continued macrophage/myofibroblast-driven fibrosis which in a disease state may result in fibrotic liver disease such as cirrhosis.²⁷